Article
[Effect of genetics, epigenetics and variations in the transcriptional expression of cadherin-E in breast cancer susceptibility].
Biomedica : revista del Instituto Nacional de Salud - 1 Dec 2016
Aristizábal-Pachón Andrés Felipe, Takahashi Catarina Satie
Abstract excerpt
INTRODUCTION: Cadherin-E (CDH1) is an important regulator of epithelial-mesenchymal transition, invasion and metastasis in many carcinomas. However, germinal epimutations and mutations effect in breast cancer susceptibility is not clear. OBJECTIVE: To evaluate rs334558 polymorphism, promoter methylation status and CDH1 expression profile in breast cancer patients. MATERIALS AND METHODS: We collected peripheral...
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