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Article

Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.

Carcinogenesis - 1 Jul 2008

Brendle Annika, Lei Haixin, Brandt Andreas, Johansson Robert, Enquist Kerstin, Henriksson Roger, Hemminki Kari, Lenner Per, Försti Asta

Abstract excerpt

Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined the effect of single-nucleotide polymorphisms (SNPs) in predicted miRNA target sites of six...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18550570
DOI: 10.1093/carcin/bgn126

Genes

ITGB4
ITGA3
ITGA6
ITGB3
ITGB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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