Article
E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
Breast cancer research and treatment - 1 Jun 2010
Beeghly-Fadiel Alicia, Lu Wei, Gao Yu-Tang, Long Jirong, Deming Sandra L, Cai Qiuyin, Zheng Ying, Shu Xiao-ou, Zheng Wei
Abstract excerpt
The epithelial transmembrane glycoprotein E-cadherin (CDH1) is necessary for intercellular adhesion, cell signaling, and maintenance of cellular differentiation; reduced expression contributes to cell proliferation, invasion, and cancer progression. Functional or potentially functional single nucleotide polymorphisms (SNPs) in E-cadherin have been previously identified and evaluated in relation to cancer risk;...
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