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Article

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2016

Rosowski Emily E, Deng Qing, Keller Nancy P, Huttenlocher Anna

Abstract excerpt

Leukocyte motility is required for host defense responses. Rac-family Rho GTPases are implicated in leukocyte function; however, the distinct roles of different Rac isoforms in host defense in vivo have remained unclear. In this study, we generated Rac2-deficient zebrafish using transcription activator-like effector nucleases to directly compare the role of Rac2 in vivo in neutrophils and macrophages in motility...

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Identifiers

PMID: 27837107
DOI: 10.4049/jimmunol.1600928
PMCID: PMC5367389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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