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Article

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish.

Disease models & mechanisms - 1 Nov 2017

Hsu Alan Y, Wang Decheng, Gurol Theodore, Zhou Wenqing, Zhu Xiaoguang, Lu Hsiu-Yi, Deng Qing

Abstract excerpt

Neutrophilic inflammation is essential for defending against invading pathogens, but can also be detrimental in many clinical settings. The hematopoietic-specific small Rho-GTPase Rac2 regulates multiple pathways that are essential for neutrophil activation, including adhesion, migration, degranulation and production of reactive oxygen species. This study tested the hypothesis that partially suppressing rac2 in...

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Identifiers

PMID: 28954734
DOI: 10.1242/dmm.030791
PMCID: PMC5719257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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