Article
Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.
Nature communications - 14 Nov 2019
Coombs Caroline, Georgantzoglou Antonios, Walker Hazel A, Patt Julian, Merten Nicole, Poplimont Hugo, Busch-Nentwich Elisabeth M, Williams Sarah, Kotsi Christina, Kostenis Evi, Sarris Milka
Abstract excerpt
Immune cells congregate at specific loci to fight infections during inflammatory responses, a process that must be transient and self-resolving. Cell dispersal promotes resolution, but it remains unclear how transition from clustering to dispersal is regulated. Here we show, using quantitative live imaging in zebrafish, that differential ligand-induced trafficking of chemokine receptors such as Cxcr1 and Cxcr2...
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