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Article

Rhomboid protease Rhbdl2 influences macrophage recruitment and wound repair in zebrafish.

The Journal of cell biology - 2 Nov 2026

Gourkanti Saroj, Ramakrishnan Gayathri, Cheung Jacqueline, Schoen Taylor J, Munoz Yazmin, Chavez Rosa M, Dohnálek Jan, Martin Katie, Lovett-Barron Matthew, Whisenant Thomas, Strisovsky Kvido, Neal Sonya E

Abstract excerpt

Wound repair requires tight control of immune cell behavior, yet the mechanisms that restrain immune-driven wound repair responses remain poorly defined. Here, we demonstrate that rhomboid intramembrane serine protease Rhbdl2 influences wound repair in zebrafish. We generated rhbdl2 mutants using CRISPR-Cas9 and found that, although Rhbdl2 is dispensable for normal development, its loss triggers enhanced wound...

Read the complete abstract on PubMed

Topics

Animals
Zebrafish
Macrophages
Wound Healing
Zebrafish Proteins
Cell Movement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Proliferation

rac GTP-Binding Proteins

Apoptosis

RAC2 GTP-Binding Protein

Mutation

Larva

Source

Identifiers

PMID: 42726127
DOI: 10.1083/jcb.202602106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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