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Article

Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model mice.

American journal of hematology - 1 Dec 2023

Barakat Amey, Jasuja Reema, Tomlinson Lindsay, Wenzel Zane, Ramaiah Lila, Petterson Betty A, Kapinos Brendon, Sawant Anagha, Pagan Vicente, Lintner Nathanael, Field Denise, Ahn Youngwook, Knee Kelly M

Abstract excerpt

Sickle cell disease (SCD) is a severe, multisystemic hematological disorder that impacts nearly every major organ in adults. The current approved treatments for SCD directly target mutant hemoglobin or address downstream disease pathology. Several compounds targeting reduction of 2,3-DPG by activation of Pyruvate Kinase-R are currently being evaluated in SCD patients. In this study, we genetically engineered a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37688507
DOI: 10.1002/ajh.27082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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