Article

Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy

2020-12-21

Abstract excerpt

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb) that affects approximately a millions people worldwide. It is characterized by a single nucleotide substitution on the β-globin gene, leading to the production of abnormal sickle hemoglobin with multi-system consequences. Mutated Hb leads to profound changes in: i) red blood cell metabolism and physiology; ii) endothelial sign...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26c0fbab-8749-5827-a83f-6a70b23452dd
DOI: 10.20944/preprints202012.0522.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sickle Cell Disease: Role of Oxidative Stress and Antioxidant TherapyDOI 10.20944/preprints202012.0522.v1Read

Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation – A Short ReviewSemantic proximity Read

Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches.Semantic proximity Read

Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate RelationshipSemantic proximity Read

Oxidative stress in β-thalassaemia and sickle cell diseaseSemantic proximity Read

Decoding the role of SOD2 in sickle cell diseaseSemantic proximity Read

Ferroptosis as an emerging target in sickle cell diseaseSemantic proximity Read

Crosstalk Between Sickle Cell Disease and FerroptosisSemantic proximity Read

Oxidative stress in sickle cell diseaseSemantic proximity Read

New insights into the pathophysiology and development of novel therapies for sickle cell diseaseSemantic proximity Read

Biomarkers and recent advances in the management and therapy of sickle cell diseaseSemantic proximity Read

Sickle Cell DiseaseSemantic proximity Read

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell AnaemiaSemantic proximity Read