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MHC class II complexes sample intermediate states along the peptide exchange pathway

9 Nov 2016

Abstract excerpt

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-known immunological concept in vertebrates, yet the conformational dynamics of antigen exchange remain elusive. By combining NMR-detected H/D exchange with Markov modelling analysis of an aggregate of 275 microseconds molecular dynamics simulations, we reveal that a stable pMHCII spontaneously samples intermediate...

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PMID: 27827392
DOI: 10.1038/ncomms13224

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