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Article

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

4 May 2023

Abstract excerpt

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree of allelic polymorphism influencing the peptide repertoire presented by the resulting MHC-II protein allotypes. During antigen processing, the human leukocyte antigen (HLA) molecule HLA-DM (DM) encounters these distinct allotypes...

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PMID: 37142807
DOI: 10.1038/s41589-023-01316-3

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