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Article

How T cell receptors interact with peptide-MHCs: a multiple steered molecular dynamics study.

Proteins - 1 Nov 2011

Cuendet Michel A, Zoete Vincent, Michielin Olivier

Abstract excerpt

The T-cell receptor (TCR) interaction with antigenic peptides (p) presented by the major histocompatibility complex (MHC) molecule is a key determinant of immune response. In addition, TCR-pMHC interactions offer examples of features more generally pertaining to protein-protein recognition: subtle specificity and cross-reactivity. Despite their importance, molecular details determining the TCR-pMHC binding remain...

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PMID: 21989928
DOI: 10.1002/prot.23104

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