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Article

Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor

14 Feb 2017

Abstract excerpt

The present work focuses on the dynamical aspects of cross-reactivity between myelin based protein (MBP) self-peptide and two microbial peptides (UL15, PMM) for Hy.1B11 T-cell receptor (TCR). This same TCR was isolated from a patient suffering from multiple sclerosis (MS). The study aims at highlighting the chemical interactions underlying recognition mechanisms between TCR and the peptides presented by Major...

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PMID: 28195200
DOI: 10.1038/srep42496

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