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Article

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.

Immunity - 1 Feb 2008

Ishizuka Jeffrey, Stewart-Jones Guillaume B E, van der Merwe Anton, Bell John I, McMichael Andrew J, Jones E Yvonne

Abstract excerpt

Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A*0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18275829
DOI: 10.1016/j.immuni.2007.12.018

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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