Article
Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2017
Ebener Simone, Barnowski Sandra, Wotzkow Carlos, Marti Thomas M, Lopez-Rodriguez Elena, Crestani Bruno, Blank Fabian, Schmid Ralph A, Geiser Thomas, Funke Manuela
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a median survival of 3 yr. IPF deteriorates upon viral or bacterial lung infection although pulmonary infection (pneumonia) in healthy lungs rarely induces fibrosis. Bacterial lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), initiating proinflammatory pathways. As TLR4 has already been linked to hepatic fibrosis and scleroderma,...
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