Article
Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2.
The international journal of biochemistry & cell biology - 1 Jan 2008
Murray Lynne A, Argentieri Rochelle L, Farrell Francis X, Bracht Michelle, Sheng Hai, Whitaker Brian, Beck Heena, Tsui Ping, Cochlin Karyn, Evanoff Holly L, Hogaboam Cory M, Das Anuk M
Abstract excerpt
One of the hallmarks of idiopathic pulmonary fibrosis with a usual interstitial pneumonia histological pathology (IPF/UIP) is excess collagen deposition, due to enhanced fibroblast extracellular matrix synthetic activity. Studies using murine models of lung fibrosis have elucidated a pro-fibrotic pathway involving IL-13 driving CCL2, which in turn drives TGFbeta1 in lung fibroblasts. Therefore, we sought to...
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