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Article

Targeting defective Toll-like receptor-3 function and idiopathic pulmonary fibrosis.

Expert opinion on therapeutic targets - 1 Apr 2015

O'Dwyer David N, Armstrong Michelle E, Kooblall Minesh, Donnelly Seamas C

Abstract excerpt

INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a disease of the lung parenchyma that is invariably fatal with a median survival of 2 - 3 years. Despite considerable progress in defining the natural history of the disease, many features of IPF pathogenesis remain poorly understood. Several recent studies have highlighted links between pattern recognition receptors of innate immunity termed 'Toll-like...

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Identifiers

PMID: 25530171
DOI: 10.1517/14728222.2014.988706

Genes

TLR3

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