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Article

Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses

7 Nov 2012

Abstract excerpt

Because recent studies implicate Toll-like receptors (TLRs) in the pathogenesis of fibrosis, we sought to investigate the in vitro and in vivo role and mechanism of TLR4-mediated fibroblast responses in fibrogenesis. We found that TLR4 was constitutively expressed, and accumulation of endogenous TLR4 ligands significantly elevated, in lesional skin and lung tissues from patients with scleroderma. Activation of...

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PMID: 23141927
DOI: 10.1016/j.ajpath.2012.09.007

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