Article
Sustained activation of toll-like receptor 9 induces an invasive phenotype in lung fibroblasts: possible implications in idiopathic pulmonary fibrosis.
The American journal of pathology - 1 Apr 2015
Kirillov Varvara, Siler Jonathan T, Ramadass Mahalakshmi, Ge Lingyin, Davis James, Grant Geraldine, Nathan Steven D, Jarai Gabor, Trujillo Glenda
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive scarring of the lung parenchyma, resulting in a steady decline of lung function and ultimately respiratory failure. The disease course of IPF is extremely variable, with some patients exhibiting stability of symptoms for prolonged periods of time, whereas others exhibit rapid progression and loss of lung function. Viral infections have been...
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