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Article

NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts.

Biochemical pharmacology - 1 Nov 2024

Nguyen Thu-Hang, Nguyen Hoang-Hanh-Nhan, Nguyen Thuy-Duong, Tran Van Thi-Hong, Nguyen Hoang-Anh, Pham Duc-Vinh

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is an irreversible progressive interstitial lung disease of unknown cause. The poorly understood pathophysiology of IPF poses substantial challenges to the development of effective anti-lung fibrotic drugs. The NLRP3 inflammasome, a key component of the innate immune system, has recently been linked to the pathogenesis of lung fibrosis. However, the specific contributions of...

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PMID: 39159876
DOI: 10.1016/j.bcp.2024.116496

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