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Article

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.

The Journal of cell biology - 21 Nov 2016

Krey Jocelyn F, Krystofiak Evan S, Dumont Rachel A, Vijayakumar Sarath, Choi Dongseok, Rivero Francisco, Kachar Bechara, Jones Sherri M, Barr-Gillespie Peter G

Abstract excerpt

With their essential role in inner ear function, stereocilia of sensory hair cells demonstrate the importance of cellular actin protrusions. Actin packing in stereocilia is mediated by cross-linkers of the plastin, fascin, and espin families. Although mice lacking espin (ESPN) have no vestibular or auditory function, we found that mice that either lacked plastin 1 (PLS1) or had nonfunctional fascin 2 (FSCN2) had...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27811163
DOI: 10.1083/jcb.201606036
PMCID: PMC5119939

Genes

PLS1
ESPN
FSCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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