Article
From structural resilience to cell specification - Intermediate filaments as regulators of cell fate.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2021
Sjöqvist Marika, Antfolk Daniel, Suarez-Rodriguez Freddy, Sahlgren Cecilia
Abstract excerpt
During the last decades intermediate filaments (IFs) have emerged as important regulators of cellular signaling events, ascribing IFs with functions beyond the structural support they provide. The organ and developmental stage-specific expression of IFs regulate cell differentiation within developing or remodeling tissues. Lack of IFs causes perturbed stem cell differentiation in vasculature, intestine, nervous...
Topics
- Animals
- Cell Differentiation
- Humans
- Intermediate Filament Proteins
- Intermediate Filaments
- Mutation
- Stem Cells
- Wnt Signaling Pathway