Article

Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance

2021-11-21

Abstract excerpt

Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require bundles of microtubules that extend through their entire length. Understanding microtubule regulation is therefore an essential aspect of axon biology. Key regulators of neuronal microtubules are the spectraplakins, a well-conserved family of cytoskeletal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44898ee9-a1db-568b-a87e-9e5bc52e57b4
DOI: 10.1101/2021.11.21.469398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenanceDOI 10.1101/2021.11.21.469398Read

Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).Semantic proximity Read

Context-specific requirements of functional domains of the Spectraplakin Short stop in vivo.Semantic proximity Read

Mouse ACF7 and drosophila short stop modulate filopodia formation and microtubule organisation during neuronal growth.Semantic proximity Read

Periodic actin structures in neuronal axons are required to maintain microtubulesSemantic proximity Read

<i>Drosophila</i> Short stop as a paradigm for the role and regulation of spectraplakinsSemantic proximity Read

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.Semantic proximity Read

The spectraplakin Short stop is an essential microtubule regulator involved in epithelial closure in Drosophila.Semantic proximity Read

The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation.Semantic proximity Read

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegenerationSemantic proximity Read

The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.Semantic proximity Read

short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension.Semantic proximity Read

Isoforms, structures, and functions of versatile spectraplakin MACF1Semantic proximity Read