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Article

Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Dec 2009

Peng Anthony W, Belyantseva Inna A, Hsu Patrick D, Friedman Thomas B, Heller Stefan

Abstract excerpt

Inner ear sensory hair cells convert mechanical stimuli into electrical signals. This conversion happens in the exquisitely mechanosensitive hair bundle that protrudes from the cell's apical surface. In mammals, cochlear hair bundles are composed of 50-100 actin-filled stereocilia, which are organized in three rows in a staircase manner. Stereocilia actin filaments are uniformly oriented with their barbed ends...

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Identifiers

PMID: 19955359
DOI: 10.1523/JNEUROSCI.2782-09.2009
PMCID: PMC2823077

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Research trail→

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Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.PMID 19955359Read ↗

β-Actin and fascin-2 cooperate to maintain stereocilia length.Semantic proximity Read ↗

Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.Semantic proximity Read ↗

Heterodimeric capping protein is required for stereocilia length and width regulation.Semantic proximity Read ↗

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.Semantic proximity Read ↗

Long isoforms of Espin and Espin-Like proteins are essential for development and maintenance of mechanotransducing stereocilia.Semantic proximity Read ↗

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.Semantic proximity Read ↗

A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil.Semantic proximity Read ↗

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Semantic proximity Read ↗

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.Semantic proximity Read ↗

Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle.Semantic proximity Read ↗

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase patternSemantic proximity Read ↗

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.Semantic proximity Read ↗

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