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Article

Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.

PloS one - 1 Jan 2011

Chou Shih-Wei, Hwang Philsang, Gomez Gustavo, Fernando Carol A, West Megan C, Pollock Lana M, Lin-Jones Jennifer, Burnside Beth, McDermott Brian M

Abstract excerpt

Stereocilia are actin-filled protrusions that permit mechanotransduction in the internal ear. To identify proteins that organize the cytoskeleton of stereocilia, we scrutinized the hair-cell transcriptome of zebrafish. One promising candidate encodes fascin 2b, a filamentous actin-bundling protein found in retinal photoreceptors. Immunolabeling of zebrafish hair cells and the use of transgenic zebrafish that...

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Identifiers

PMID: 21625653
DOI: 10.1371/journal.pone.0014807
PMCID: PMC3082522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.PMID 21625653Read ↗

β-Actin and fascin-2 cooperate to maintain stereocilia length.Semantic proximity Read ↗

Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.Semantic proximity Read ↗

Regionalized protein localization domains in the zebrafish hair cell kinociliumSemantic proximity Read ↗

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.Semantic proximity Read ↗

Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice.Semantic proximity Read ↗

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase patternSemantic proximity Read ↗

Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.Semantic proximity Read ↗

β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia MaintenanceSemantic proximity Read ↗

Heterodimeric capping protein is required for stereocilia length and width regulation.Semantic proximity Read ↗

An Atomic Model of Actin Filaments Cross-Linked by Fimbrin and Its Implications for Bundle Assembly and FunctionSemantic proximity Read ↗

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Semantic proximity Read ↗

The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.Semantic proximity Read ↗

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