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Article

β-Actin and fascin-2 cooperate to maintain stereocilia length.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 May 2013

Perrin Benjamin J, Strandjord Dana M, Narayanan Praveena, Henderson Davin M, Johnson Kenneth R, Ervasti James M

Abstract excerpt

Stereocilia are actin-based protrusions on auditory sensory hair cells that are deflected by sound waves to initiate the conversion of mechanical energy to neuronal signals. Stereocilia maintenance is essential because auditory hair cells are not renewed in mammals. This process requires both β-actin and γ-actin as knock-out mice lacking either isoform develop distinct stereocilia pathology during aging. In...

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Identifiers

PMID: 23658152
DOI: 10.1523/JNEUROSCI.0238-13.2013
PMCID: PMC3718021

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