Article
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice.
Human molecular genetics - 1 Jan 2015
Taylor Ruth, Bullen Anwen, Johnson Stuart L, Grimm-Günter Eva-Maria, Rivero Francisco, Marcotti Walter, Forge Andrew, Daudet Nicolas
Abstract excerpt
Hearing relies on the mechanosensory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of their actin-rich stereociliary bundles into electrochemical signals. Several actin-associated proteins are essential for stereocilia formation and maintenance, and their absence leads to deafness. One of the most abundant actin-bundling proteins of stereocilia is plastin 1, but its...
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