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Article

Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice.

Biochemical and biophysical research communications - 2 Dec 2016

Jin Jianfeng, Wang Dayong, Xiao Haifeng, Wei Huiyan, Matunda Cedric, Zhang He, Li Xin, Wang Chuxuan, Zou Chaoxia, Gao Xu, Zhao Weiming, Li Qiang

Abstract excerpt

Heme oxygenase (HO) is the rate-limiting enzyme in heme metabolism. HO-1 exhibits anti-oxidative and anti-inflammatory function via the actions of its metabolite, respectively. A growing body of evidence demonstrates that HO-1 is implicated in the pathogenesis and progression of several types of cancer. However, whether HO-1 takes part in healthy-premalignant-malignant transformation is still undefined. In this...

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PMID: 27810363
DOI: 10.1016/j.bbrc.2016.10.148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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