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Article

Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice.

Cancer research - 15 Dec 2005

Busuttil Rita A, Garcia Ana Maria, Cabrera Carlos, Rodriguez Armando, Suh Yousin, Kim Woo Ho, Huang Ting-Ting, Vijg Jan

Abstract excerpt

Reactive oxygen species have been implicated as a cause of cancer and aging in mammals. Mice deficient for the antioxidant enzyme CuZn-superoxide dismutase (Sod1) have a decreased life span and an elevated incidence of liver cancer. To test the hypothesis that the cancer-prone phenotype in such mice is due to accelerated spontaneous mutation accumulation, we crossed these mutants with mice harboring a neutral...

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PMID: 16357131
DOI: 10.1158/0008-5472.CAN-05-2980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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