Article
Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.
Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2001
Zhou Z Q, Manguino D, Kewitt K, Intano G W, McMahan C A, Herbert D C, Hanes M, Reddick R, Ikeno Y, Walter C A
Abstract excerpt
O(6)-methylguanine (O(6)mG) is a potent mutagenic and procarcinogenic DNA lesion. Organisms have evolved with a DNA repair mechanism that largely ameliorates the deleterious effects of O(6)mG through a direct reversal mechanism by a protein termed O(6)-methylguanine-DNA methyltransferase (MGMT). However, the contribution of O(6)mG to carcinogenesis, in the absence of known exposure to agents that produce it, has...
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