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Article

Clinical Significance of Heme Oxygenase 1 in Tumor Progression

17 May 2021

Abstract excerpt

Heme oxygenase 1 (HO-1) plays a key role in cell adaptation to stressors through the antioxidant, antiapoptotic, and anti-inflammatory properties of its metabolic products. For these reasons, in cancer cells, HO-1 can favor aggressiveness and resistance to therapies, leading to poor prognosis/outcome. Genetic polymorphisms of HO-1 promoter have been associated with an increased risk of cancer progression and a...

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PMID: 34067625
DOI: 10.3390/antiox10050789

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