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Article

Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs.

Reproductive biology and endocrinology : RB&E - 3 Nov 2016

Kang Jung-Taek, Cho Bumrae, Ryu Junghyun, Ray Caitlin, Lee Eun-Jin, Yun Yun-Jin, Ahn SunMi, Lee JinSeok, Ji Dal-Young, Jue Nathaniel, Clark-Deener Sherrie, Lee Kiho, Park Kwang-Wook

Abstract excerpt

BACKGROUND: Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, we report generation and phenotypic characterization of IL2RG knockout female pigs produced through combination of...

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Identifiers

PMID: 27809915
DOI: 10.1186/s12958-016-0206-5
PMCID: PMC5095964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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