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RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency

28 Jun 2014

Abstract excerpt

Pigs share many physiological, biochemical, and anatomical similarities with humans and have emerged as valuable large animal models for biomedical research. Considering the advantages in immune system resemblance, suitable size, and longevity for clinical practical and monitoring purpose, SCID pigs bearing dysfunctional RAG could serve as important experimental tools for regenerative medicine, allograft and...

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PMID: 24973446
DOI: 10.4049/jimmunol.1400915

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