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Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

9 Aug 2022

Abstract excerpt

Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo expansion of human hepatocytes. Here we report on the generation of RAG2-/-IL2Rγ-/YFAH-/- (RGFKO) pigs via CRISPR/Cas9 system and somatic cell nuclear transfer. We...

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PMID: 36032112
DOI: 10.3389/fimmu.2022.950194

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