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Article

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

Immunity - 1 Aug 1999

Cha S S, Kim M S, Choi Y H, Sung B J, Shin N K, Shin H C, Sung Y C, Oh B H

Abstract excerpt

TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

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Source

Identifiers

PMID: 10485660
DOI: 10.1016/s1074-7613(00)80100-4

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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