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Article

Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome.

Arthritis and rheumatism - 1 Nov 2007

Han Bing, Moore Paul A, Wu Jiangping, Luo Hongyu

Abstract excerpt

OBJECTIVE: Decoy receptor 3 (DcR3), a tumor necrosis factor receptor family member, is a secreted protein that can enhance cell survival by interfering with multiple apoptosis pathways. This study was undertaken to investigate the role of DcR3 in the pathogenesis of autoimmune disease. METHODS: We generated transgenic mice with actin promoter-driven expression of human DcR3 and investigated the development of...

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Identifiers

PMID: 17968950
DOI: 10.1002/art.22978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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