Article
Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure.
Journal of molecular biology - 3 Aug 2012
Luo Jinquan, Obmolova Galina, Malia Thomas J, Wu Sheng-Jiun, Duffy Karen E, Marion James D, Bell Jessica K, Ge Peng, Zhou Z Hong, Teplyakov Alexey, Zhao Yonghong, Lamb Roberta J, Jordan Jarrat L, San Mateo Lani R, Sweet Raymond W, Gilliland Gary L
Abstract excerpt
Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response through the formation of a signaling unit (SU) composed of one double-stranded RNA (dsRNA) and two TLR3 molecules. We report the crystal structure of human TLR3 ectodomain (TLR3ecd) in a quaternary complex with three neutralizing Fab fragments. Fab15 binds an epitope that overlaps the C-terminal dsRNA binding site and, in...
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