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Article

Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2010

Cheung Timothy C, Coppieters Ken, Sanjo Hideki, Oborne Lisa M, Norris Paula S, Coddington Amy, Granger Steven W, Elewaut Dirk, Ware Carl F

Abstract excerpt

The TNF superfamily member homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpesvirus entry mediator (HVEM), a receptor expressed by T lymphocytes (LIGHT) [TNF superfamily (SF)-14], is a key cytokine that activates T cells and dendritic cells and is implicated as a mediator of inflammatory, metabolic, and malignant diseases. LIGHT engages the lymphotoxin-beta...

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Identifiers

PMID: 20592286
DOI: 10.4049/jimmunol.1001159
PMCID: PMC2921593

Genes

TNF
TNFRSF14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.PMID 20592286Read ↗

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