Article
Molecular characterization of a CD95 signaling mutant.
Arthritis and rheumatism - 1 Jun 1998
Peterson E J, Latinis K M, Koretzky G A
Abstract excerpt
OBJECTIVE: To study the intracellular signaling events associated with ligation of the surface receptor CD95. METHODS: A mutant clone of Jurkat T cells, DD3, which fails to transmit apoptotic signals through CD95, was selected for study. Surface expression of CD95 and the primary nucleotide sequence of CD95, as well as the functional effects of a mutant CD95 molecule found in DD3, were examined. RESULTS: DD3,...
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