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Article

Development of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons.

Scientific reports - 11 Jan 2021

Hagan Rebecca, Rex Elizabeth, Woody David, Milewski Monika, Glaza Thomas, Maher Michael P, Liu Yi

Abstract excerpt

L-type calcium channels (LTCCs) are highly expressed in the heart and brain and are critical for cardiac and neuronal functions. LTCC-blocking drugs have a long and successful record in the clinic for treating cardiovascular disorders. In contrast, establishment of their efficacy for indications of the central nervous system remains challenging given the tendency of existing LTCC drugs being functionally and...

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Identifiers

PMID: 33432098
DOI: 10.1038/s41598-020-80692-5
PMCID: PMC7801380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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