Article

Cannabinoid inhibition of mechanosensitive K+ channels

2024-12-10

Abstract excerpt

Cannabidiol (CBD) is a prominent non-psychoactive small molecule produced by cannabis plants used clinically as an antiepileptic. Here, we show CBD and other cannabinoids are potent inhibitors of mechanosensitive two-pore domain K+ (K2P) channels, including TRAAK and TREK-1 that contribute to spike propagation in myelinated axons. Five TRAAK mutations that cause epilepsy or the neurodevelopmental syndrome FHEIG (f...

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Identifiers and source

Literature Corpus work: 411692fa-7904-52e7-a9e2-ca0a73923a00
DOI: 10.1101/2024.12.09.627564

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