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Article

Redistribution of EC‐SOD resolves bleomycin‐induced inflammation via increased apoptosis of recruited alveolar macrophages

27 Sept 2019

Abstract excerpt

A human single nucleotide polymorphism (SNP) in the matrix‐binding domain of extracellular superoxide dismutase (EC‐SOD), with arginine to glycine substitution at position 213 (R213G), redistributes EC‐SOD from the matrix into extracellular fluids. We reported that, following bleomycin (bleo), knockin mice harboring the human R213G SNP (R213G mice) exhibit enhanced resolution of inflammation and protection...

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PMID: 31560857
DOI: 10.1096/fj.201901038rr

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