Article
Superoxide dismutase 3, extracellular (SOD3) variants and lung function.
Physiological genomics - 13 May 2009
Ganguly Koustav, Depner Martin, Fattman Cheryl, Bein Kiflai, Oury Tim D, Wesselkamper Scott C, Borchers Michael T, Schreiber Martina, Gao Fei, von Mutius Erika, Kabesch Michael, Leikauf George D, Schulz Holger
Abstract excerpt
Polymorphisms in Superoxide dismutase 3, extracellular (SOD3) have been associated with reduced lung function and susceptibility to chronic obstructive pulmonary disease (COPD) in adults. Previously, we identified SOD3 as a contributing factor to altered ventilation efficiency (dead space volume/total lung capacity) in mice. Because SOD3 protects the extracellular matrix of the lung, we hypothesized that SOD3...
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