Article
M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells.
Circulation journal : official journal of the Japanese Circulation Society - 25 Nov 2016
Mahati Endang, Li Peili, Kurata Yasutaka, Maharani Nani, Ikeda Nobuhito, Sakata Shinji, Ogura Kazuyoshi, Miake Junichiro, Aiba Takeshi, Shimizu Wataru, Nakasone Naoe, Ninomiya Haruaki, Higaki Katsumi, Yamamoto Kazuhiro, Nakai Akira, Shirayoshi Yasuaki, Hisatome Ichiro
Abstract excerpt
BACKGROUND: Long QT syndrome 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). Most of its mutations give rise to unstable hERG proteins degraded by the proteasome. Recently, carbachol was reported to stabilize the wild-type hERG-FLAG via activation of the muscarinic type 3 receptor (M3-mAChR). Its action on mutant hERG-FLAG, however, remains uninvestigated.Methods and Results:A...
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