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Article

Express with caution: Epitope tags and cDNA variants effects on hERG channel trafficking, half-life and function.

Journal of cardiovascular electrophysiology - 1 Sept 2017

Osterbur Badhey Marika L, Bertalovitz Alexander C, McDonald Thomas V

Abstract excerpt

INTRODUCTION: Genetic mutations in KCNH2, which encodes hERG, the alpha subunit of the potassium channel responsible for the IKr current, cause long QT syndrome (LQTS), an inherited cardiac arrhythmia disorder. Electrophysiology techniques are used to correlate genotype with molecular phenotype to determine which mutations identified in patients diagnosed with LQTS are disease causing, and which are benign. These...

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Source

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Identifiers

PMID: 28544109
DOI: 10.1111/jce.13259
PMCID: PMC5671924

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Express with caution: Epitope tags and cDNA variants effects on hERG channel trafficking, half-life and function.PMID 28544109Read ↗

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