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Article

Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2.

International journal of molecular sciences - 23 Feb 2021

Bakhos-Douaihy Dalal, Seaayfan Elie, Demaretz Sylvie, Komhoff Martin, Laghmani Kamel

Abstract excerpt

Mutations in the Na-K-2Cl co-transporter NKCC2 lead to type I Bartter syndrome, a life-threatening kidney disease. We previously showed that export from the ER constitutes the limiting step in NKCC2 maturation and cell surface expression. Yet, the molecular mechanisms involved in this process remain obscure. Here, we report the identification of chaperone stress 70 protein (STCH) and the stress-inducible heat...

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Source

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Identifiers

PMID: 33672238
DOI: 10.3390/ijms22042207
PMCID: PMC7926544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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