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Article

NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2.

Clinical and experimental pharmacology & physiology - 1 Nov 2017

Huo JianHua, Guo Xueyan, Lu Qun, Qiang Hua, Liu Ping, Bai Ling, Huang Christopher Lh, Zhang Yanmin, Ma Aiqun

Abstract excerpt

Loss of function mutations in the human ether-a-go-go-related gene (hERG) cause long QT syndrome type 2 (LQT2). Most LQT2 patients are heterozygous mutation carriers in which the mutant hERG exerts potent dominant-negative effects. 1, 3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is known to enhance IKr in WT-hERG. We investigated its actions following lipofectamine-induced expression of both mutant...

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PMID: 28741726
DOI: 10.1111/1440-1681.12820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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