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Article

The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.

Cell calcium - 1 Feb 2012

Katano Masahiro, Numata Tomohiro, Aguan Kripamoy, Hara Yuji, Kiyonaka Shigeki, Yamamoto Shinichiro, Miki Takafumi, Sawamura Seishiro, Suzuki Toshimitsu, Yamakawa Kazuhiro, Mori Yasuo

Abstract excerpt

The transient receptor potential M2 channel (TRPM2) is the Ca(2+)-permeable cation channel controlled by cellular redox status via β-NAD(+) and ADP-ribose (ADPR). TRPM2 activity has been reported to underlie susceptibility to cell death and biological processes such as inflammatory cell migration and insulin secretion. However, little is known about the intracellular mechanisms that regulate oxidative...

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Source

Identifiers

PMID: 22226147
DOI: 10.1016/j.ceca.2011.12.011

Genes

TRPM2
EFHC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.PMID 22226147Read ↗

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