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Article

Identification and functional characterization of the human ether-a-go-go-related gene Q738X mutant associated with hereditary long QT syndrome type 2.

International journal of molecular medicine - 1 Sept 2014

Han Sheng-Na, Yang Song-Hua, Zhang Yu, Sun Xiao-Yan, Duan Yan-Yan, Hu Xiang-Jie, Fan Tian-Li, Huang Chen-Zheng, Yang Ge, Zhang Zhao, Zhang Lirong

Abstract excerpt

QT interval prolongation, a risk factor for arrhythmias, may be associated with genetic variants in genes governing cardiac repolarization. Long QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go‑go-related gene (hERG). This gene encodes a voltage-gated potassium channel comprised of 4 subunits, and the formation of functional channels requires the proper assembly of these 4 subunits. In the...

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PMID: 24993425
DOI: 10.3892/ijmm.2014.1827

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Identification and functional characterization of the human ether-a-go-go-related gene Q738X mutant associated with hereditary long QT syndrome type 2.PMID 24993425Read ↗

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