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Article

Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment.

PloS one - 1 Jan 2014

Ding Wei-Guang, Xie Yu, Toyoda Futoshi, Matsuura Hiroshi

Abstract excerpt

We herein investigated the effect of low temperature exposure on the expression, degradation, localization and activity of human Kv1.5 (hKv1.5). In hKv1.5-expressing CHO cells, the currents were significantly increased when cultured at a reduced temperature (28°C) compared to those observed at 37°C. Western blot analysis indicated that the protein levels (both immature and mature proteins) of hKv1.5 were...

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Identifiers

PMID: 24663680
DOI: 10.1371/journal.pone.0092923
PMCID: PMC3963980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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